leafyelgreen.gif (1505 bytes)Success Rates / Pregnancy Rates...

What was learned from the 1995 CDC pregnancy rate information.
How to increase pregnancy rates without increasing patient care.
Statistics 101

How to increase pregnancy rates without increasing patient care

The Wyden-law was approved by Congress and the U.S. President in 1992 to inform the public about clinics' success rates and to allow comparisons among ART providers. Although the spirit of the law is a noble one, this law has actually given the patient a sense of security that simply DOES NOT exist! Major emphasis has been put on complying with the law rather than on educating the patient, setting standards to report pregnancy rates, or improving the educational and expertise level of service providers.

Under the actual form that the statistics are collected you cannot compare clinics for the following reasons:

  • Acceptance Policy

The criterion to accept patients differs among clinics. Some patients may not be accepted in a program just because their probability of success looks clinically low. More difficult cases are simply referred to other clinics or simply put on "long waiting lists". Therefore, clinics that selectively accept patients may end up with higher pregnancy rates than those clinics that are stiff bound to the old philosophy of providing treatment to all those that come to their doors. In other cases, difficult patients are put into "research' groups where their outcomes are not utilized when compiling statistics.


 

The criterion to offer ART alternatives to patients is not uniform among clinics. Some patients may be moved soon to advanced reproductive technologies at the outset of their treatment bypassing "lower technology" treatments like IUI if applicable. For example they may be offered IVF instead of IUI, or they may be offered ICSI when again IUI or IVF would have been the first choice! Other groups offer "special deals" to qualified (selected) patients. These policies ensure that the patients with higher probability of pregnancy will end up pregnant utilizing techniques that perhaps they did not need.

The criterion for cycle cancellation is not uniform among IVF centers. Some institutions are going to cancel a cycle at the first sign of trouble so the success rates will not be affected. Others will put the interest of the couple first to give them the chance of having a child of their own provided that there is a reasonable chance of success.

The number of embryos transferred. This is a variable not controlled when providing success rates. The number of embryos transferred affects not only the success rates but also the probability of a multiple pregnancy. Published information shows that the number of embryos transferred increases the probability of pregnancy, and reaches a plateau beyond the transfer of 3-4 embryos. We consider it to be highly unethical to enhance the probability of pregnancy at the expense of increasing the chances of a high order multiple pregnancy. Potential injury to the fetus associated with brain damage and immaturity of other organs are some of the consequences of a multiple pregnancy. There is also the economic stress and the added pressure of taking care of several infants of the same age.

Fresh vs. Frozen embryos. Since frozen embryos tend to have a lower pregnancy rate than fresh embryos, there is pressure to transfer as many fresh embryos as possible so the "statistics" are not affected.

Selective information. Some patients may be offered selective information to encourage them to enroll as patients (positive selection), others are given a less bright environment to encourage them to go somewhere else (negative selection). However, under the present medical ethical standards ALL patients, regardless of their probability of pregnancy, should be given the medical treatment they deserve. It should be the patients' choice to select a clinic and not vice versa.

As it stands right now, delivery rates provided to you by ANY clinic reflect circumstances that occurred at least NINE months ago. The 1995 statistics were just published in March of 1998! If a particular clinic had an event 12-18 months ago that affected their pregnancy and delivery rates positively or negatively, such a circumstance may no longer be present. Therefore, you are making a decision based on events that may not reflect the current status.

Current statistics, as reported to CDC, are a snap picture of events that occurred in a twelve month period. They do not reflect the life-time performance of the clinic you are scrutinizing. Would you rather make investment decisions based on a 12 month performance or on the historic performance of a particular portfolio? We firmly believe that the cumulative performance of the clinic offers a more stable picture than just a 12 month period.

The statistics offered by a particular clinic are a combination of different factors: staff experience, patient demographics, clinic policies, etc... that may not apply to your particular case. It is not always the case that the clinic with the best statistics provides the best overall health care. It does not mean that the statistics given are your real chances of success. They represent just a fraction of ALL the patients treated in a given year in the whole US. Therefore, if you are using statistics use them to evaluate YOUR probability of pregnancy and do not utilize the statistics as a main criterion to choose a clinic. Yearly national statistics about ART are more reliable than those from an individual clinic. National statistics that involve lifetime records are even better and more solid. Remember, the greater the population where data is gathered from, the more reliable that information is.

Baby05.jpg (9212 bytes)Most couples fix their attention on their desire to have a baby. However, in addition to help you expand your family, it is the responsibility of your physician to help you pay attention to the REASONS for your infertility. In some cases, the causes may be too irrelevant to make an impact on your life or in your offspring. An example of this may be a previous tubal ligation or a failed vasovasostomy (re-attachment of the vas-deferens after a vasectomy). However, you may be in a category where the underlying cause of your infertility may have a negative impact on your offspring. It is your physician's responsibility to bring those facts to your attention so you can make an informed decision.

Should I be put on a waiting list? No! Waiting lists are utilized in a way to place patients with low probability of pregnancy at the end while moving rapidly patients with higher probability of conception to the top of the list. Of course, two years later you simply give up and go to another physician. If you are a typical infertile woman, in your mid 30s, you cannot afford to spend 2 years on a waiting list. Even one year may be too much for you. One of the main determinants for you to achieve a pregnancy is your age. The younger you are, the higher the probability you may have to have your own child(ren). As you approach the late 30s your chances of pregnancy with your genetic child drop dramatically, forcing you to consider donor eggs for pregnancy.

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