Recent studies have shown an increased link of infertility with immunological events. In fact it appears that most of the so called "Unexplained Infertility" may have a underlying immunological component. Although, it appears to be generally accepted that there is an immunological component in certain cases of infertility, the treatment options have elicited a great deal of controversy. At this moment there is no agreement on what is the best treatment alternative, and it appears that in some cases unjustified claims have put some treatments above others. Some of those treatments are particularly expensive and not without danger.